cobicistat
CAS 1004316-88-4
Cobicistat helps HIV medicines stay active long enough to work. It blocks the liver enzyme that would clear the main treatment drugs too quickly.
Synthesis Routes
$764.63/g(51.7% margin)
Gross margin from 10 synthesis routes across askcos
Rank
Engine
Materials
1ASKCOS3$715.37$764.63/g--4 materials
Route 1 · ASKCOS · 3 steps · 4 starting materials
$715.37/g synthesis → $764.63/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OCc1cncs1)Oc1ccc([N+](=O)[O-])cc1
O=C(OCc1cncs1)Oc1ccc([N+](=O)[...
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
CNCc1csc(C(C)C)n1
CNCc1csc(C(C)C)n1
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CNCc1csc(C(C)C)n1 | $9.75/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(OCc1cncs1)Oc1ccc([N+](=O)[ | $0.68/g |
| Synthesis cost (stoichiometric) | $715.37/g |
| Retail price | $1,480.00/g |
| Gross margin | $764.63/g |
2ASKCOS4$715.52$764.48/g--5 materials
Route 2 · ASKCOS · 4 steps · 5 starting materials
$715.52/g synthesis → $764.48/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OCc1cncs1)Oc1ccc([N+](=O)[O-])cc1
O=C(OCc1cncs1)Oc1ccc([N+](=O)[...
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
O=C(Oc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](...
O=C(Oc1ccc([N+](=O)[O-])cc1)Oc...
↓produces
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(CCN1CCOCC1)...
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(C...
Made in Step 3
Step 4
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(CCN1CCOCC1)...
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(C...
Made in Step 3
+
CNCc1csc(C(C)C)n1
CNCc1csc(C(C)C)n1
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CNCc1csc(C(C)C)n1 | $9.75/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(OCc1cncs1)Oc1ccc([N+](=O)[ | $0.68/g |
| O=C(Oc1ccc([N+](=O)[O-])cc1)Oc | $0.39/g |
| Synthesis cost (stoichiometric) | $715.52/g |
| Retail price | $1,480.00/g |
| Gross margin | $764.48/g |
3ASKCOS4$715.63$764.37/g--5 materials
Route 3 · ASKCOS · 4 steps · 5 starting materials
$715.63/g synthesis → $764.37/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OCc1cncs1)Oc1ccc([N+](=O)[O-])cc1
O=C(OCc1cncs1)Oc1ccc([N+](=O)[...
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
O=C(Cl)Oc1ccc([N+](=O)[O-])cc1
O=C(Cl)Oc1ccc([N+](=O)[O-])cc1
↓produces
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(CCN1CCOCC1)...
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(C...
Made in Step 3
Step 4
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(CCN1CCOCC1)...
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(C...
Made in Step 3
+
CNCc1csc(C(C)C)n1
CNCc1csc(C(C)C)n1
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CNCc1csc(C(C)C)n1 | $9.75/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(Cl)Oc1ccc([N+](=O)[O-])cc1 | $1.00/g |
| O=C(OCc1cncs1)Oc1ccc([N+](=O)[ | $0.68/g |
| Synthesis cost (stoichiometric) | $715.63/g |
| Retail price | $1,480.00/g |
| Gross margin | $764.37/g |
4ASKCOS3$715.65$764.35/g--5 materials
Route 4 · ASKCOS · 3 steps · 5 starting materials
$715.65/g synthesis → $764.35/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
+
OCc1cncs1
OCc1cncs1
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
CNCc1csc(C(C)C)n1
CNCc1csc(C(C)C)n1
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CNCc1csc(C(C)C)n1 | $9.75/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl | $1.00/g |
| OCc1cncs1 | $1.00/g |
| Synthesis cost (stoichiometric) | $715.65/g |
| Retail price | $1,480.00/g |
| Gross margin | $764.35/g |
5ASKCOS3$715.75$764.25/g--5 materials
Route 5 · ASKCOS · 3 steps · 5 starting materials
$715.75/g synthesis → $764.25/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OCc1cncs1)Oc1ccc([N+](=O)[O-])cc1
O=C(OCc1cncs1)Oc1ccc([N+](=O)[...
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
CNCc1csc(C(C)C)n1
CNCc1csc(C(C)C)n1
+
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CNCc1csc(C(C)C)n1 | $9.75/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl | $1.00/g |
| O=C(OCc1cncs1)Oc1ccc([N+](=O)[ | $0.68/g |
| Synthesis cost (stoichiometric) | $715.75/g |
| Retail price | $1,480.00/g |
| Gross margin | $764.25/g |
6ASKCOS4$715.81$764.19/g--6 materials
Route 6 · ASKCOS · 4 steps · 6 starting materials
$715.81/g synthesis → $764.19/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
+
OCc1cncs1
OCc1cncs1
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
O=C(Oc1ccc([N+](=O)[O-])cc1)Oc1ccc([N+](...
O=C(Oc1ccc([N+](=O)[O-])cc1)Oc...
↓produces
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(CCN1CCOCC1)...
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(C...
Made in Step 3
Step 4
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(CCN1CCOCC1)...
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(C...
Made in Step 3
+
CNCc1csc(C(C)C)n1
CNCc1csc(C(C)C)n1
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CNCc1csc(C(C)C)n1 | $9.75/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl | $1.00/g |
| O=C(Oc1ccc([N+](=O)[O-])cc1)Oc | $0.39/g |
| OCc1cncs1 | $1.00/g |
| Synthesis cost (stoichiometric) | $715.81/g |
| Retail price | $1,480.00/g |
| Gross margin | $764.19/g |
7ASKCOS4$715.91$764.09/g--6 materials
Route 7 · ASKCOS · 4 steps · 6 starting materials
$715.91/g synthesis → $764.09/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
+
OCc1cncs1
OCc1cncs1
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
O=C(Cl)Oc1ccc([N+](=O)[O-])cc1
O=C(Cl)Oc1ccc([N+](=O)[O-])cc1
↓produces
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(CCN1CCOCC1)...
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(C...
Made in Step 3
Step 4
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(CCN1CCOCC1)...
O=C(NC(CCC(Cc1ccccc1)NC(=O)C(C...
Made in Step 3
+
CNCc1csc(C(C)C)n1
CNCc1csc(C(C)C)n1
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CNCc1csc(C(C)C)n1 | $9.75/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(Cl)Oc1ccc([N+](=O)[O-])cc1 | $1.00/g |
| O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl | $1.00/g |
| OCc1cncs1 | $1.00/g |
| Synthesis cost (stoichiometric) | $715.91/g |
| Retail price | $1,480.00/g |
| Gross margin | $764.09/g |
8ASKCOS3$716.03$763.97/g--5 materials
Route 8 · ASKCOS · 3 steps · 5 starting materials
$716.03/g synthesis → $763.97/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
+
OCc1cncs1
OCc1cncs1
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
CNCc1csc(C(C)C)n1
CNCc1csc(C(C)C)n1
+
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CNCc1csc(C(C)C)n1 | $9.75/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(OC(Cl)(Cl)Cl)OC(Cl)(Cl)Cl | $1.00/g |
| OCc1cncs1 | $1.00/g |
| Synthesis cost (stoichiometric) | $716.03/g |
| Retail price | $1,480.00/g |
| Gross margin | $763.97/g |
9ASKCOS4$718.37$761.63/g--5 materials
Route 9 · ASKCOS · 4 steps · 5 starting materials
$718.37/g synthesis → $761.63/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OCc1cncs1)Oc1ccc([N+](=O)[O-])cc1
O=C(OCc1cncs1)Oc1ccc([N+](=O)[...
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
CN=C=O
CN=C=O
↓produces
CNC(=O)NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1cccc...
CNC(=O)NC(CCN1CCOCC1)C(=O)NC(C...
Made in Step 3
Step 4
CNC(=O)NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1cccc...
CNC(=O)NC(CCN1CCOCC1)C(=O)NC(C...
Made in Step 3
+
CC(C)c1nc(CO)cs1
CC(C)c1nc(CO)cs1
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CC(C)c1nc(CO)cs1 | $25.00/g |
| CN=C=O | $1.00/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(OCc1cncs1)Oc1ccc([N+](=O)[ | $0.68/g |
| Synthesis cost (stoichiometric) | $718.37/g |
| Retail price | $1,480.00/g |
| Gross margin | $761.63/g |
10ASKCOS4$718.61$761.39/g--5 materials
Route 10 · ASKCOS · 4 steps · 5 starting materials
$718.61/g synthesis → $761.39/g margin
Step 1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
NC(CCC(N)Cc1ccccc1)Cc1ccccc1
+
O=C(OCc1cncs1)Oc1ccc([N+](=O)[O-])cc1
O=C(OCc1cncs1)Oc1ccc([N+](=O)[...
↓produces
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
Step 2
NC(CCC(Cc1ccccc1)NC(=O)OCc1cncs1)Cc1cccc...
NC(CCC(Cc1ccccc1)NC(=O)OCc1cnc...
Made in Step 1
+
NC(CCN1CCOCC1)C(=O)O
NC(CCN1CCOCC1)C(=O)O
↓produces
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
Step 3
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1ccccc1)NC(=...
NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1c...
Made in Step 2
+
CNC(=O)Cl
CNC(=O)Cl
↓produces
CNC(=O)NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1cccc...
CNC(=O)NC(CCN1CCOCC1)C(=O)NC(C...
Made in Step 3
Step 4
CNC(=O)NC(CCN1CCOCC1)C(=O)NC(CCC(Cc1cccc...
CNC(=O)NC(CCN1CCOCC1)C(=O)NC(C...
Made in Step 3
+
CC(C)c1nc(CO)cs1
CC(C)c1nc(CO)cs1
↓produces
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCOCC2)C(=O)N...
CC(C)c1nc(CN(C)C(=O)NC(CCN2CCO...
Target
| CC(C)c1nc(CO)cs1 | $25.00/g |
| CNC(=O)Cl | $2.60/g |
| NC(CCC(N)Cc1ccccc1)Cc1ccccc1 | $12.00/g |
| NC(CCN1CCOCC1)C(=O)O | $2921.60/g |
| O=C(OCc1cncs1)Oc1ccc([N+](=O)[ | $0.68/g |
| Synthesis cost (stoichiometric) | $718.61/g |
| Retail price | $1,480.00/g |
| Gross margin | $761.39/g |
Vendor Pricing
$1,480.00/g15.6x gold
Combi-Blocks, Inc. (US) -- 1 g -- 97% purityBuy →
All 17 vendors
| Vendor | Country | Buy | |||||
|---|---|---|---|---|---|---|---|
| Combi-Blocks, Inc. | $1,480.00 | $1480 / 1 g | 97% | US | 2d | -- | Buy → |
| Baoji Guokang Healthchem Co., Ltd.Web | $2,063.00 | $2063 / 1 g | -- | CN | -- | -- | Buy → |
| MedKoo Biosciences, Inc | $3,250.00 | $3250 / 1 g | 98% | US | 11d | -- | Buy → |
| Angene Chemical | $4,014.00 | $4014 / 1 g | 98% | HK | 7d | 3g | Buy → |
| A2B Chem LLC | $4,090.00 | $409 / 100 mg | 98% | US | 9d | -- | -- |
| BLD Pharmatech Ltd. | $4,384.00 | $1096 / 250 mg | 98% | CN | 5d | -- | -- |
| Aaron Chemicals LLC | $4,388.00 | $1097 / 250 mg | 98% | HK | 10d | 1.25g | Buy → |
| AA BLOCKS | $4,450.00 | $445 / 100 mg | 98% | US | 9d | -- | -- |
| Molnova | $4,780.00 | $478 / 100 mg | 99% | CN | 7d | -- | Buy → |
| AstaTech, Inc | $4,970.00 | $497 / 100 mg | 95% | US | 4d | -- | Buy → |
| TargetMol Chemicals | $5,310.00 | $531 / 100 mg | 99.62% | US | 12d | 0.8358g | Buy → |
| TargetMol Chemicals EU | $5,310.00 | $531 / 100 mg | 99.62% | AT | 6d | 0.12792g | Buy → |
| TargetMol Chemicals US | $5,310.00 | $531 / 100 mg | 99.62% | US | 4d | 0.1398g | Buy → |
| Apexbio Technology LLC | $6,050.00 | $1210 / 200 mg | 99.94% | US | 3d | -- | Buy → |
| MedChemExpress MCE | $8,941.90 | $894.19 / 100 mg | 99.77% | SE | 6d | -- | -- |
| Angene International Limited | $11,820.00 | $1182 / 100 mg | 98% | US | 12d | 0.1g | Buy → |
| Cayman Europe | $36,176.00 | $904.4 / 25 mg | 98% | EE | 9d | -- | Buy → |
Identity
Namecobicistat
CAS1004316-88-4
FormulaC40H53N7O5S2
Mol Weight776.0
Kindcompound
DTXSIDDTXSID00143269
PubChem CID25151504
InChIKeyZCIGNRJZKPOIKD-CQXVEOKZSA-N
SMILES
CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5Drug Labelers
Drug IngredientA-S Medication SolutionsE.R. Squibb & Sons, L.L.C.Esteve Quimica, SAGilead Sciences, Inc.Honour Lab LimitedJanssen Ortho LLCJanssen Products LPJanssen Products, LPMSN Life Sciences Private LimitedMatrix Pharmacorp Private LimitedPatheon Inc.Yuhan Chemical
Sectors & Uses
Sectors
Health
Downstream Uses
PREZCOBIXGenvoyaPREZCOBIX PEDStribildTybostSymtuzaEVOTAZ